Diffuse cutaneous melanosis: Rare complication of metastatic melanoma

Diffuse cutaneous melanosis is a rare complication of metastatic melanoma related to a worse prognosis. there are few cases reported in the literature. its pathogenesis has not been completely elucidated,although studies have suggested certain mechanisms for its occurrence. it is clinically manifested as a blue-gray discoloration of the skin and mucous membranes in a cephalo caudal progression and usually associated with melanuria. skin and mucosa histopathology reveals only the presence of melanophages in the dermis,mainly perivascular,and free interstitial melanin. we report the case of a 68-year-old male with metastatic melanoma,diffuse hyperpigmentation of the skin and melanuria. © 2017 by anais brasileiros de dermatologia.