How relevant are vascular endothelial growth factor and intercellular adhesion molecule in the systemic capillary leak syndrome of psoriasis?

Psoriasis is a chronic disease,characterized by erythematous scaly lesions,presented in eight different forms: plaques,guttate,pustular,erythrodermic,inverse,nail and scalp psoriasis,and psoriatic arthritis. its development depends on genetic factors,external stimulus and immune response alteration.¹ proinflammatory cytokines such as tnf-alpha,il-12 and 23 may also be involved. in the worst cases,systemic complications linked to endothelial alterations may occur. a literature review was conducted for a better understanding of what roles vegf (vascular endothelial growth factor) and icam-1 (intercellular adhesion molecule) have,among other cytokines,in systemic capillary leak syndrome,involved in erythrodermic and pustular psoriasis,the most unstable forms of the disease. © 2017 by anais brasileiros de dermatologia.