Chronic granulomatous disease associated with common variable immunodeficiency - 2 clinical cases

Introduction: chronic granulomatous disease associated with common variable immunodefi- ciency (gd-cvid),although well documented,is rare. granulomatous lesions can affect several organs and are histologically indistinguishable from sarcoidosis. clinical cases: case 1: a 39-year-old male patient with cvid,asymptomatic although with thrombocytopenia and mediastinal-hilar adenopathies. gd-cvid was diagnosed by bone marrow biopsy. progressive clinical and radiological improvement was obtained with corticotherapy. case 2: a 38-year-old male patient with cvid,suffered from asthenia,anorexia,myalgia,lower limbs edemas,and dry cough. he had mediastinal and bilateral hilar adenopathies within which biopsy revealed non-necrotizing granulomatous infiltrate. a spontaneous resolution was detected after 9 months of evolution. conclusion: gd-cvid is rare and can mimetize other pathologies,namely,sarcoidosis; it should therefore be publicized and discussed so that it becomes a general clinical knowledge. © 2013 sociedade portuguesa de pneumologia.