IN VIVO EVALUATION OF ELECTROSPUN POLY (VINYL ALCOHOL)/SODIUM ALGINATE NANOFIBROUS MAT AS WOUND DRESSING

In this study, potential of the alginate based electrospun nanofibrous mats as wound dressings was investigated macroscopically in vivo experiments. 2/1 (v/v) %9 pva / %1 naalg nanofibrous mats were produced by electrospinning method. in order to improve water resistance of the electrospun mats, the cross-linking was performed. sem analyses, thickness and air permeability tests were applied for the nanofibrous mats produced as wound dressing and suprasorb-a commercial alginate wound dressing. in vivo experiments, the healing performances of the wounds dressed by using cotton gauze, bactigras, suprasorb-a and the electrospun pva/naalg nanofibrous mat were macroscopically evaluated and compared. the wound healing potential of the electrospun mat was better than that of cotton gauze including a drug and looked like antibacterial bactigras. the results indicated that the electrospun pva/naalg nanofibrous mat as wound dressing provided a good means for wound healing.