Solubility of sodium phenytoin in propylene glycol + water mixtures in the presence of β-cyclodextrin

Background: poor aqueous solubility of drugs is still a challenging aspect in drug discovery and development. solubilization techniques such as cosolvency and complexation are used to solubilize poorly soluble drugs. a number of mathematical models presented for predicting the solubility of drugs in water+cosolvent mixtures and the jouyban-acree model promises more accuracy when compared with other algorithms. methods: solubility of sodium phenytoin in binary mixtures of propylene glycol + water in the presence of beta-cyclodextrin (β-cd) along with the solubility of sodium phenytoin in this solvent mixture in the absence of β-cd using saturating shake flask method were studied. the generated solubility data was fitted to the jouyban-acree model and the solubility profile of drug in the presence of β-cd was compared with solubility data in the absence of β-cd. results: the solubility was increased by addition of propylene glycol and was decreased by addition of beta-cyclodextrin. the measured solubility data were used to evaluate the correlation ability of the jouyban-acree model employing the solubility data in monosolvent. these findings are supported by acceptable mean relative deviations values obtained when comparing the estimated and experimental solubilities. conclusion: the addition of β-cd was decreased the solubilization power of propylene glycol. © 2015 the authors.