>
Fa   |   Ar   |   En
   Optimization of cefixime nanosuspension to improve drug dissolution  
   
نویسنده ghasemian e. ,rezaeian b. ,alaei s. ,vatanara a. ,ramezani v.
منبع pharmaceutical sciences - 2015 - دوره : 21 - شماره : 3 - صفحه:136 -144
چکیده    Background: the aim of this study was to prepare and characterize cefixime nanosuspensions in order to enhance the dissolution rate and solubility of this drug. methods: nanosuspensions were prepared using sonoprecipitation method and the effects of surfactant type,surfactant and solid content,sonication power input and interval of acid addition on the yield and particle size of nanosuspensions were investigated. results: particle size and yield of the optimal nanosuspension formulation were 266±10 nm and 35±2%,respectively. scanning electron microscopy (sem) results showed a nearly spherical morphology for cefixime nanoparticles. thermal analysis indicated that there was a partial crystalline structure in the nanoparticles and in vitro dissolution rate of the drug was significantly increased by the reduction in particles size. conclusions: sonoprecipitation was shown to be a successful method to produce cefixime nanosuspensions and the optimum conditions of the process were introduced. © 2015 the authors.
کلیدواژه Cefixime; Dissolution rate; Factorial design; Nanosuspension; Optimization; Solubility
آدرس tehran university of medical sciences tums, ایران, tehran university of medical sciences tums, ایران, tehran university of medical sciences tums, ایران, tehran university of medical sciences tums, ایران, pharmaceutics department,faculty of pharmacy,tehran university of medical sciences,tehran,iran,department of pharmaceutics,faculty of pharmacy,shahid sadoughi university of medical sciences, ایران
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved