Morphine Decreased Peritoneal Adhesion in Addicted Male Rats after Abdominal Surgery

Background: after abdominal surgery, postoperative adhesion is a serious problemthat threats the patients. the present study evaluated the protective effects of morphineon abdominal adhesion in an experimental model in rat. materials: an experimentalintraabdominal adhesion model was created in 24 adult male rats by ischemic bottommethod. the animals were divided into three groups. the control group was nottreated by morphin. in the morphine group, the animals received morphine as 10mg/kg once a day for three days after surgery. in group 3, the addicted animals tomorphine received morphine as 10 mg/kg daily after surgery. drug dependency wasconfirmed by naloxone. adhesions were evaluated by nair and swollon scoring system10 days after surgery. results: there was a significant differences regard to the length(p < .05), thickness (p < .05), and severity of adhesions (p < .05) among the control,morphine, and morphine-addicted groups. conclusion: morphine reduced the severityof postoperative adhesions the present study. morphine could affect postoperationadhesion through suppression of inflammation. it is suggested that opioid receptor(s)might involve in this process. therefore, selective ligands could be used and offer apharmacologic strategy in preventing adhesion formation.