Synthesis of Some New Macrocyclic Diamides Based on Dibenzosulfide

Background: 18-memberd ring of tri-aza dibenzo sulfide (ttd) and dibenzosulfoxide (tsd) macrocyclic diamides showed the oxidative radical forming abilityand further strengthened the documentation of their cytotoxicity effects through lipids,proteins and dna oxidation damages. with this in mind, our group synthesized somenovel macrocyclic base on ttd diamides and a podand methods: novel azamacrocyclic diamides were synthesized based on dibenzosulfide using of diestermethod as n-pivot lariat ethers from the michael reaction and nucleophilic attack toepoxide ring as a key strategy of corresponding diamide with acrylonitrile, epoxystyreneand 1, 2-epoxypropane at reflux in dichloromethane in good overall yields. inaddition, a podand was synthesized based on dibenzosulfoxide with epichlorohydrin atreflux in methanol. results: the structures of these compounds were confirmed usingir, 1h nmr and 13c nmr spectroscopy. conclusion: the presence of additionaloxygen atom considerably increases its hydrogen binding capacity and this propertycan improve biological and complexation characteristics of primary 18-memberedringtri-aza macrocyclic diamide (ttd).