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   vesicular carriers for follicular drug delivery  
   
نویسنده amirinejad mostafa ,haghighizadeh atoosa ,etemad leila ,rajabi omid
منبع pharmaceutical sciences - 2025 - دوره : 31 - شماره : 1 - صفحه:22 -42
چکیده    The follicular route has been explored for both topical and systemic drug delivery but its application is challenged by different limitations such as sebum flow and size-selectivity. vesicular carriers like liposomes, niosomes, invasomes, and transferosomes, which have shown promise in overcoming these barriers, have been explored in this review study. these vesicles improve follicular penetration of drugs, with deformable carriers performing better than conventional liposomes. also, modifying liposomes using permeation enhancers has been introduced as another choice to enhance their follicular penetration. vesicular systems have been primarily used to deliver drugs for treating alopecia, acne, and topical infections. they have also demonstrated potential in systemic delivery of antihypertensive drugs and insulin. local hair massage and iontophoresis techniques further improve vesicle follicular penetration.
کلیدواژه invasome ,intrafollicular ,liposome ,niosome ,transferosome ,transfollicular
آدرس mashhad university of medical sciences, school of pharmacy, department of pharmaceutics, iran. ferdowsi university of mashhad, faculty of science, department of chemistry, iran, mashhad university of medical sciences, school of pharmacy, department of pharmaceutical control, iran, mashhad university of medical sciences, school of pharmacy, pharmaceutical research center, pharmaceutical technology institute, department of pharmaceutical control, iran, mashhad university of medical sciences, school of pharmacy, targeted drug delivery research center, pharmaceutical technology institute, department of pharmaceutical control, iran
پست الکترونیکی rajabio@mums.ac.ir
 
     
   
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