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major bioactive prenylated flavonoids from humulus lupulus l., their applications in human diseases and structure-activity relationships (sar) – a review
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نویسنده
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comert onder ferah ,kalin sevil ,sahin nebahat ,davutlar gulce ,abusharkh khaled a.n. ,maraba ozlem ,hal rabia selina ,ay mehmet ,nahar lutfun ,sarker satyajit d.
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منبع
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pharmaceutical sciences - 2024 - دوره : 30 - شماره : 1 - صفحه:1 -20
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چکیده
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In recent years, the incidence of cancers, inflammatory diseases, alzheimer’s disease, glucose metabolism disorder and diabetes has increased alarmingly which demands more research into the discovery of new drug candidates to treat these human diseases. main phytochemicals from humulus lupulus l. (hops) have been demonstrated to have positive impacts on human health, and prenylated flavonoids are one of the major groups of bioactive phytochemicals found in this plant. thus, this review summarizes the role of major prenylated components in hops in human diseases including cancer, inflammation and viral infections. in silico studies of prenylated bioactive compounds against various drug targets such as histone deactylases (hdacs), sirtuins (sirts), and acetylcholinesterase (ache), and the molecular molecular interactions between protein and ligand have also been included. furthermore, the structure-activity relationships (sar) studies on these compounds are highlighted. this review concludes that the prenylated phytochemicals from h. lupulus l., including xanthohumol (xn), isoxanthohumol (ixn), 8-prenylnaringenin (8-pn) and 6-prenylnaringenin (6-pn), have promising roles in human health and may contribute to new drug discovery and development.
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کلیدواژه
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cancer ,humulus lupulus l. ,in silico ,phytotherapeutics ,preclinical trial ,xanthohumol
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آدرس
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çanakkale onsekiz mart university, faculty of medicine, department of medical biology, turkey, çanakkale onsekiz mart university, school of graduate students, department of medical system biology, turkey, çanakkale onsekiz mart university, school of graduate students, department of medical system biology, turkey, çanakkale onsekiz mart university, school of graduate students, department of medical system biology, turkey, çanakkale onsekiz mart university, faculty of science, department of chemistry, natural products and drug research laboratory, turkey. al-quds university, faculty of science and technology, department of chemistry and chemical technology, palestine, çanakkale onsekiz mart university, school of graduate students, department of medical system biology, turkey, çanakkale onsekiz mart university, faculty of medicine, turkey, çanakkale onsekiz mart university, faculty of science, department of chemistry, natural products and drug research laboratory, turkey, palacký university and institute of experimental botany, the czech academy of sciences, laboratory of growth regulators, czech, liverpool john moores university, centre for natural products discovery, school of pharmacy and biomolecular sciences, uk
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پست الکترونیکی
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s.sarker@ljmu.ac.uk
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Authors
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