the effects of vitamin k2 (menaquinone-7) on the leptin and adiponectin levels in overweight/obese type 2 diabetes patients: a randomized clinical trial

Background: type 2 diabetes mellitus (t2dm) is a prevalent disease with metabolic consequences. lower levels of adiponectin and higher levels of leptin were reported in t2dm. this study aimed to evaluate the effect of menaquinone-7 (mk-7) supplementation on adiponectin and leptin in overweight/obese t2dm patients. methods: sixty men and women with t2dm and 27 ≤ body mass index < 35 kg/m², participated in this double-blind placebo-controlled randomized clinical trial for 12 weeks. the subjects were allocated into intervention (200 µg/day mk-7) or placebo groups. three-day food records, anthropometrics and physical activity were assessed and fasting blood samples were collected at the pre- and post-intervention. serum adiponectin, leptin, fasting blood sugar (fbs) and fasting insulin (fi) were measured and adiponectin to leptin ratio (a/l ratio) was calculated. results: mk-7 decreased fasting blood sugar (p: 0.018) and fasting insulin (p: 0.012), according to a within group analysis of the 45 patients who finished the research. fasting blood sugar (p: 0.024) and leptin levels (p: 0.032) were lower in the mk-7 group, but there were no significant changes between the groups in terms of adiponectin or the adiponectin to leptin (a/l) ratio. conclusion: current study showed that mk-7 supplementation could lead to significant reduction in leptin and fbs, but it has no effect on the adiponectin and a/l ratio in overweight/ obese t2dm patients.