influence of choline-based ionic liquids as neoteric green solvents on aqueous solubility of lamotrigine and piroxicam drugs

Background: new compounds called choline-based ionic liquids (ils) that are environmentally friendly have become more attractive. in this study, some choline-based ils (choline lactate (chla) and choline propionate (chpro)) have been used to increase the aqueous solubility of lamotrigine (ltg) and piroxicam (pxm) at t = 298.15 to 313.15 k. methods: ils were prepared and purified. the solubility of drugs in the aqueous ils solutions was measured at different temperatures with shake flask method. results: th e solubility of the investigated drugs increased with increasing the weight fraction of ils. the solubility data were correlated by e-nrtl, wilson, apelblat and λh (buchowski) models. conclusion: the aqueous solubility of drugs depends on both the weight fraction of co-solvents and the solution temperature. these two essential parameters were analyzed through some semi-empirical and activity coefficient models getting the average relative deviation percent as e-nrtl (3.09%) < wilson (3.92%) (for full range concentration of co-solvent) and apelblat (3.52%) < λh (buchowski) (5.11%) (for the dilute region of co-solvent). in addition, the results show that the aqueous solubility increases with rising temperature and there are strong interactions between the drug and the ils.