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solubilization methods for paclitaxel and docetaxel: an overview
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نویسنده
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pourkarim fariba ,rahimpour elaheh ,alvani sima ,jouyban abolghasem
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منبع
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pharmaceutical sciences - 2022 - دوره : 28 - شماره : 2 - صفحه:208 -223
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چکیده
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Cancer is still a serious disease with high incidence over the past decades. many anticancer drugs are discovered and used to treat cancer, among them, taxanes such as paclitaxel and docetaxel have high lipophilicity and low aqueous solubility which is further magnified considering the strong need for administering them by intravenous infusion. currently, the poor water-solubility of taxanes is improved by prodrug formation, conjugation, inclusion complexation, micellar solubilization and liposome-based formulations. recent achievements for solubilization of taxanes are reviewed and critically discussed regarding their pharmaceutical and chemical applications.
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کلیدواژه
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docetaxel ,paclitaxel ,poor water ,solubility -solubilization methods -taxanes
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آدرس
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tabriz university of medical sciences, student research committee, faculty of pharmacy, drug applied research center, iran, tabriz university of medical sciences, pharmaceutical analysis research center and faculty of pharmacy, food and drug safety research center, iran, tabriz university of medical sciences, biotechnology research center, immunology research center, iran, tabriz university of medical sciences, pharmaceutical analysis research center and faculty of pharmacy, kimia idea pardaz azarbayjan (kipa) science based company, iran
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پست الکترونیکی
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ajouyban@hotmail.com
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Authors
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