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promising antibacterial effect of copper oxide nanoparticles against several multidrug resistant uropathogens
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نویسنده
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sedigh ebrahim-saraie hadi ,heidari hamid ,rezaei vahid ,mortazavi mohammad javad ,motamedifar mohammad
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منبع
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pharmaceutical sciences - 2018 - دوره : 24 - شماره : 3 - صفحه:213 -218
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چکیده
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Background: recently, nanotechnology has been demonstrated to be a promising application to overcome the problem of antibiotic resistance. in the present study, we aimed to determine the antibacterial activity of copper oxide nanoparticles (cuo nps) on several multipledrug resistant (mdr) uropathogenic strains. methods: this in vitro casecontrol study was performed on 4 uropathogenic bacteria including staphylococcus aureus, enterococcus faecalis, escherichia coli and pseudomonas aeruginosa. the antibacterial property was evaluated by well diffusion method at different concentrations of cuo nps. results: overall, nps concentration of 10, 25 and 50 μg/ml showed the remarkable antibacterial activity. a lower effect was seen against s. aureus strains. cuo nps exhibited maximum bacterial growth inhibition against e. faecalis strains. in most of the cases, the zone of inhibition in 50 μg/ml concentration was closest to control positive antibiotics. conclusion: in summary, cuo nps as an alternative to conventional antibiotics that are currently used showed dosedependent on antibacterial activity against different uropathogens, specificity towards pathogenic grampositive bacteria. this promising antibacterial activity of cuo nps suggesting the development of nps coatings on the different surface of biomedical materials for applications in different antimicrobial control systems.
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کلیدواژه
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antibacterial effect ,nanoparticles ,copper oxide ,uropathogen strains
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آدرس
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shiraz university of medical sciences, nanomedicine and nanobiology research center, school of medicine, department of bacteriology and virology, ایران, shiraz university of medical sciences, nanomedicine and nanobiology research center, school of medicine, department of bacteriology and virology, ایران, shiraz university of medical sciences, nanomedicine and nanobiology research center, ایران, shiraz university of medical sciences, school of medicine, department of medical physics and medical engineering, ایران, shiraz university of medical sciences, nanomedicine and nanobiology research center, school of medicine, shiraz hiv/aids research center, institute of health, department of bacteriology and virology, ایران
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پست الکترونیکی
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motamedm@yahoo.com
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Authors
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