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   cytotoxicity and acute gastrointestinal toxicity of bacterial cellulose-poly (acrylamide-sodium acrylate) hydrogel: a carrier for oral drug delivery  
   
نویسنده pandey manisha ,choudhury hira ,mohd amin mohd cairul iqbal
منبع pharmaceutical sciences - 2016 - دوره : 22 - شماره : 4 - صفحه:291 -295
چکیده    Background: preliminary safety evaluation of polymer intended to use as drug delivery carrier is essential. methods: in this study polyacrylamide grafted bacterial cellulose (bc/am) hydrogel was prepared by microwave irradiation initiated free radical polymerization. the synthesized hydrogel was subjected to in vitro cytotoxicity and acute gastrointestinal toxicity studies to evaluate its biological safety as potential oral drug delivery carrier. results: the results indicate that hydrogel was non cytotoxic and did not show any histopathological changes in gi tract after a high dose of oral administration. conclusion: the results revealed that hydrogel composed of bacterial cellulose and polyacrylamide is safe as oral drug delivery carrier.
کلیدواژه bacterial cellulose ,polyacrylamide ,cytotoxicity ,acute oral toxicity ,microwave ,irradiation
آدرس international medical university, school of pharmacy, malaysia. universiti kebangsaan malaysia, faculty of pharmacy, centre for drug delivery research, malaysia, international medical university, school of pharmacy, malaysia, universiti kebangsaan malaysia, faculty of pharmacy, centre for drug delivery research, malaysia
پست الکترونیکی mciamin@pharmacy.ukm.my
 
     
   
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