اتوآنتی‌باد‌های طبیعی علیه آنتی‌ژن‌های سطحی گلبول‌های قرمز در اهداکنندگان خون سالم

Abstractbackground and objectivesnatural autoantibodies (n-auto-abs) are a class of antibodies that are formed without any previous provocation against their own. currently an important role has been proposed for these antibodies in immune homeostasis; as we can study them as biological markers to predict the onset of the disease. for the first time, we studied the prevalence of n-auto-abs against rbc antigens as well as the prevalence of cold antibodies in blood donors.materials and methodsthree hundred healthy individuals who donated at tehran blood transfusion center were selected randomly; their blood samples were collected including 289 (96.3%) males and 11 (3.7%) female. their age range is within 17-64 years. edta plasma was evaluated for the study of n-auto-abs that reacted at 4c. results28 individuals (9.34%) showed positive reaction with their own cell suspension. in addition, 55 individuals (18.34%) were positive for cold antibodies.conclusions twenty eight individuals (9.34%) showed positive reaction with their own cell suspension. in addition, 55 individuals (18.34%) were positive for cold antibodies.