ارتباط بین پلی‌مورفیسم (rs2333227) G-436 A در پروموتر ژن میلوپراکسیداز و خطر ابتلا به گرفتگی عروق کرونر در بیماران ایرانی

Abstractbackground and objectivespolymorphonuclear cell-derived myeloperoxidase (mpo) is a known agent in the progression of inflammatory disorders via the production of reactive oxygen species. in this study, we investigated the association between rs2333227 polymorphism (g-436 a) within the mpo gene promoter and coronary artery stenosis.materials and methodsa total of 160 iranian subjects (patients = 86 and controls = 74) were introduced on the basis of the study criteria. dna was extracted from white blood cells and the genotype distribution was evaluated by pcr-rflp technique.resultsthe aa, ag and gg genotype frequencies in study population were calculated to be 6.90%, 39.4% and 53.7%, respectively (p > 0.21). there was no significant difference between the genotype distribution and the extent of coronary stenosis in patients with 1vd, 2vd and 3vd (p = 0.71). the a allele frequencies were 25.6% and 27.4% in patients and controls, respectively.conclusionsin general, our results indicate that the iranian population genotype and allele distribution do not play a role in the development and severity of coronary artery disease.