ارزیابی پلی‌مورفیسم‌های رایج ژن CYP2C19 در بیماران تحت درمان با داروی کلوپیدوگرل

Abstractbackground and objectivesclopidogrel is one of the most commonly prescribed drugs to prevent ischemic events following coronary syndromes or stent placement. the objective of this study was to evaluate the prevalence of the cytochrome p450 (cyp450) 2c19 enzyme (cyp2c19) genotypes in the iranian population.materials and methodscyp2c19 (*1/*2/*3) variants were analyzed using polymerase chain reaction-restriction length polymorphism (pcr–rflp) assays in a representative sample of 154 iranian patients with ischemic heart disease in peyvand laboratory.resultsin this study, out of 154 iranian patients the frequency rates of cyp2c19 *2 were 36 (23.4%) in heterozygous and 6 (3.9%) in homozygous forms; 112 (72.7%) patients had the normal genotype.conclusionsfda recommendations are more useful to be practiced in our country than other countries. physicians should identify patients and advise them to consider other antiplatelet medications or alternative dosing strategies in poor metabolizers.