ارتباط پلی‌مورفیسم 4G/5G در پروموتر ژن PAI-1 با سندروم سقط مکرر

Abstractbackground and objectivesone of the factors known to cause thrombophilia in women with unexplained recurrent spontaneous abortion (rsa) is the 4g/5g polymorphisms in the promoter region of the ‍‍plasminogen activator inhibitor-1(pai-1). this study aimed to determine the association between rsa and this polymorphism in iranian patients.materials and methodsin this case-control study, 30 patients with the background of two or more consecutive unexplained abortions and 10 women with at least two live births without a miscarriage who referred to baqiyatallah hospital and avicenna infertility clinic were analyzed for the pai-1 4g/5g promoter polymorphism by the pcr-rflp method. results achieved from estimating the genotype of this polymorphism were analyzed by the spss16 and chi square. results4g allele frequency was 46.7 % in the patient group and 40% in the control group. frequency of the pai-1 4g/5g promoter polymorphism was 76.7% in patients and 80% in controls. for pai-1 4g/5g promoter polymorphism, 60% of patients and 80% of controls were heterozygote. furthermore, 16.7% of patients were homozygote, though there were not any homozygote in controls.conclusionsthese findings failed to support the relationship between pai-1 4g/5g promoter polymorphism and the increasing risk of rsa in evaluated iranian women.