|
|
Repressing of SOX6 and SOX9 in Situ Chondrogenic Differentiation of Rat Bone Marrow Stromal Cells
|
|
|
|
|
نویسنده
|
Karimfar Mohammad Hassan ,Peyvandi Aliasghar ,Noorozian Mohsen ,Ahmadi Roozbahani Navid ,Mastery Farahani Reza ,Khoramgah Maryam Sadat ,Azimi Hadi ,Bahadori Monfared Ayad ,Abbaszadeh Hojjat-Allah
|
منبع
|
anatomical sciences journal - 2015 - دوره : 12 - شماره : 2 - صفحه:75 -82
|
چکیده
|
Introduction: sox9 is a transcriptional activator which is necessary for chondrogenesis. sox6 are closely related to dna-binding proteins that critically enhance its function. therefore, to carry out the growth plate chondrocyte differentiation program, sox9 and sox6 collaborate genomewide. chondrocyte differentiation is also known to be promoted by glucocorticoids through unknown molecular mechanisms.methods: we investigated the effects of asynthetic glucocorticoid, dexamethasone (dex), on sox9 gene expression in chondrocytes.results: sox9 mrna was expressed at high levels in these chondrocytes. treatment with dex resulted in enhancement of sox9 mrna expression. the dex effect was dose dependent (0·5 nm and 1 nm).conclusion: rt-pcr analysis revealed that dex also enhanced the levels of sox9 expression. it was observed that dex had enhancing effect only on sox9; the expression level was low for sox6. it can thus be concluded that chondrocyte differentiation can be promoted by dex via sox9 enhancement.
|
کلیدواژه
|
SOX6 ,SOX9 ,Bone marrow stromal cells ,Differentiation
|
آدرس
|
zahedan university of medical sciences, Faculty of Medicine, Department of Anatomical Sciences, ایران, shahid beheshti university of medical sciences, Hearing Disorders Research Center, ایران, shahid beheshti university of medical sciences, School of Medicine, Department of Biology and Anatomical Sciences, ایران, shahid beheshti university of medical sciences, Hearing Disorders Research Center, ایران, shahid beheshti university of medical sciences, School of Medicine, Department of Biology and Anatomical Sciences, ایران, shahid beheshti university of medical sciences, School of Medicine, Department of Medical Biotechnology, ایران, shahid beheshti university of medical sciences, School of Medicine, Department of English Language Teaching, ایران, shahid beheshti university of medical sciences, Faculty of Medicine, Department of Health & Community Medicine, ایران, shahid beheshti university of medical sciences, School of Medicine, Hearing Disorders Research Center, Department of Biology and Anatomical Sciences, ایران
|
پست الکترونیکی
|
hoomanabs@gmail.com dr.abbaszadeh@sbmu.ac.ir
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|