The Study of Effect of Levofloxacin on Disorders of Female Hormones in Rats

introduction: levofloxacin is one of the antibiotics with wide treatment application which isoften applied for treating infections of genitourinary system and lower respiratory tract. notingthat most antibiotics can affect the structure of ovary tissue, we have launched research into theeffect of levofloxacin on hormone disorder resulting from tissue damage.methods: in this survey, 40 wistar rats with the weight of 20±25 gr and approximate age of 8weeks were used. they were divided into 4 groups with 10 rats. the study groups were tube fedwith 200, 500 and 750 mml of levofloxacin for each kg of weight. the control group didn’treceive anything. duration of the survey lasted 22 days. the rats were under 12 hours light-darkcycle, 24.7-26.4 temperature and 55-66% humidity. after the termination of this term, the bloodsample was taken from their hearts and the serums were sent to clinical laboratory so as the levelof hormone to be measured.results: titration of level of lh, fsh, prog hormones revealed that there was significantdecrease of the level of hormone after consuming antibiotics in comparison with that of controlgroup.conclusion: levofloxacin antibiotic is one of the factors which can destroy ovary tissue, andgives rise to hormone disorder. this point should be considered in case of administration of drugs.