Could Melissa Officinalis Extract Restore Streptozotocin-Induced Spatial Memory Impairment in Rats?

Introduction: alzheimer disease is a progressive and irreversible neuropsychiatric disorder. melissa officinalis improves anxiety and clinical dementia symptoms caused by ad; therefore, the purpose of the present study was to evaluate the effect of mellisa extract on spatial memory deficit induced by stz in mwm examination of male wistar rats. methods: in the present study, 112 male wistar rats (220-270g) were used. spatial learning deficit was induced by bilateral icv injection of stz (3mg/kg) via cannula; then, the melissa extract in different doses administrated by gavage; and morris water maze for measurement of spatial learning parameters was performed. results: the results of this study demonstrated that gavage of the 200mg/kg of melissa officinalis in combination with stz, followed by significant reduction in two parameters: time and distance. conclusion: totally, the data indicate possible therapeutic value of m. officinalis extract on spatial learning improvement.