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Safety and Efficacy of Placental Mesenchymal StemCell-derived Extracellular Vesicle in Severe COVID-19Patients: Phase I & II Clinical Trials
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نویسنده
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jahedi zargar mehdi ,heidari keshel saeed ,kaviani saeid ,zahraei mohammad ,izadyari aghmiuni azadeh ,amir savadkoohi ali ,jamaati hamidreza ,samet mohammad ,soufizomorrod mahsa ,soufi zomorrod mina ,heidari faeze sadat ,mirjalili mohamad reza ,tabarsi payam ,soroush mohammadreza ,aliannejad rasoul ,javani mojtaba ,shafiii hosein ,vasei mohammad ,soleimani masoud
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منبع
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anatomical sciences journal - 2022 - دوره : 19 - شماره : 2 - صفحه:79 -88
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چکیده
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Introduction: most mortality in covid-19 cases was due to the increased inflammatorycytokines and cytokine storm. as mesenchymal stem cells (mscs) possess immunomodulatoryproperties, this study assessed the therapeutic effects of placental msc-derived extracellularvesicles on the inflammation and pulmonary injury caused by covid-19.methods: the study was carried out in phases i (safety study, 101 patients) and ii (efficacystudy, 80 patients) in a randomized, double-blind study at four hospital centers from april 2021to august 2021. in addition to standard treatments, 15 ml of normal saline solution containing15×109 vesicles was injected intravenously for five consecutive days.
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کلیدواژه
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COVID‐19 ,Extracellularvesicles ,Mesenchymalstromal cell ,Placenta-derivedmesenchymal stem cell ,Acuterespiratory distress syndrome
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آدرس
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tarbiat modares university, faculty of medical science, department of hematology, Iran, shahid beheshti university of medical sciences, school of advanced technologies in medicine, department of tissue engineering and applied cell sciences, Iran, tarbiat modares university, faculty of medical sciences, department of hematology, iran, west nikan hospital, nikan education & research center (nerc), Iran, pasteur institute of iran, department of nanobiotechnology, Iran, mehrad hospital, department of anesthesia and critical care, Iran, shahid beheshti university of medical sciences, national research and institute of tuberculosis and lung diseases (nritld), chronic respiratory disease research center, Iran, shahid sadoughi university of medical sciences, shahid sadoughi hospital, department of internal medicine, iran, national institute of genetic engineering and biotechnology (nigeb), Iran, tarbiat modares university, faculty of medical science, department of applied cell science and hematology, iran, shahid sadoughi university of medical sciences, infectious diseases research center, school of medicine, shahid sadoughi general hospital, department of infectious diseases, Iran, shahid sadoughi university of medical sciences, faculty of medicine, department of anesthesia and intensive care medicine, iran, shahid beheshti university of medical sciences, clinical tuberculosis and epidemiology research center, national research institute of tuberculosis and lung diseases (nritld), iran, west nikan hospital, nikan education & research center (nerc), iran, tehran university of medical sciences, shariati hospital, pulmonary department, iran, shahid sadughi hospital, Iran, shahid sadughi hospital, Iran, tehran university of medical sciences, cell therapy based research center, digestive disease research institute, shariati hospital, iran, shahid beheshti university of medical sciences, school of advanced technologies in medicine, department of tissue engineering and applied cell science, iran. tarbiat modares university, faculty of medical science, department of applied cell science and hematology, Iran
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پست الکترونیکی
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soleim_m@modares.ac.ir
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Authors
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