Neural Tube Biology With Emphasis on Early Neurulation;A Narrative Review

Neurulation, as the formation of the basis of the nervous system, is the earliest and crucialstage of embryonic development, affecting the development of other parts of the embryonicbody. during neurulation, the neural plate is formed through morphological changes. atthe end of this stage, the neural tube is established and the central nervous system could beformed in the future. although this embryonic process occurs morphologically, the precisestudy of nervous system evolution can be considered by different gene mutations in rodentembryos. genetic assessments of embryos can finally cause the accurate discovery ofthe role of genes in embryo development, the stages of nervous system development,and possible associated diseases. explanation of new findings in the field of neurulationwith emphasis on genetics can be helpful in future embryonic studies, abnormalities,and treatments. thus, the study of neural plate formation can play an important role inincreasing the insight of embryological researchers in this field. in this review article,we aimed to collect basic embryonic data in rodent neurulation to provide importantinformation for more laboratory investigations in this field.