The Necessity of Multiple Revision of the First Draft of an Article

Background and Objectives: Multiple sclerosis (MS) is an autoimmune neurodegenerative disease of the central nervous system (CNS). Although, the contribution of various cells such as B cells, CD8+ T cells, microglia/macrophages, dendritic cells, asterocytes and mast cells in the pathogenesis of MS have been demonstrated, however, it seems that autoreactive myelin specific CD4+ T cells play a central role in pathological events contributing in MS pathogenesis. The aim was to evaluate the recent findings regarding the properties of T lymphocyte subsets and their roles in pathogenesis of MS disease. Functionally, distinct effector T cells are induced from na iuml;ve T cells upon antigenic stimulation, including Th1, Th2, Th17, Th22, Th9, and regulatory T (Treg) cells which are characterized based on their cytokine patterns. Of the activated T cells, Th1 cells secreting IFN gamma;, Th17 cells producing IL17, Th9 releasing IL9, and Th22 secreting IL22 play major roles in MS development, while Th2 cells producing IL4, and Treg cells secreting IL10 and TGF beta; have been associated with a reduction of CNS inflammation and improvement of MS. The modulation of Th1, Th17, Th9 and Th22 cells activity and the promotion of Th2 and Treg cellrelated responses can be more consider for immunological treatment of MS disease.Key words: Multiple sclerosis, Th1, Th2, Th9, Th17, Th22, TregHow to cite this article: Etesam Z, Nemati M, Jafarzadeh A. The Role of T Lymphocyte Subsets in The Pathogenesis of Multiple Sclerosis J Rafsanjan Univ Med Sci 2016; 15(3): 25780. [Farsi]