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Background and Objectives: Sick building syndrome (SBS) is a buildingrelated illness in which people in the environment do not experience proper physical and mental wellbeing. Mental and physical changes include headache, nausea, abnormal fatigue, lack of concentration, sensation of an unpleasant odor. Thus, the aim of this study was to investigate the frequency of SBS and its related factors in nurses at Ali Ibn Abitaleb hospital in Rafsanjan City in 2018.Materials and Methods: This crosssectional study was performed using standard MM040EA questionnaire related to SBS and indoor air quality at Ali Ibn Abitaleb hospital in Rafsanjan city in 2018. 285 nurses in different wards of the hospital were entered the study using census method. Data were analyzed by descriptive statistics and chisquare test.: The mean ± standard deviation of age for participating nurses was 34.04 ±7.90 years. Fatigue 88 (63.8%), dry hands and itching and red skin 71 (51.4%) were the most frequent symptoms of SBS among the nurses. 68 (49.3%) nurses complained of unpleasant odors of the workplace every week, and 77 (56.2%) nurses felt their workload was sometimes high. Demographic characteristics, work environment and working conditions did not show any statistically significant difference with the frequency of SBS (p>0.05).: Due to the high frequency of SBS in hospital nurses and its effects on performance and productivity, it is necessary to reengineer the hospital environment and improve the work environment, especially ventilation of hospital wards.Key words: Sick building syndrome, Work environment, Nurses, Hospital wards, RafsanjanThis study was funded by Rafsanjan University of Medical Sciences.Conflict of interest: None declared.Ethical approval: The Ethics Committee of Rafsanjan University of Medical Sciences approved the study (IR.RUMS.REC.1397.113). How to cite this article: Khodadadi H, Mobini Lotfabad M, Shykh Ali Babaie Mahani F, Mahbobi rad M, AsadPour M, Eslami H, Khajeh Hosseini Sh, Bagherinasab H. Frequency of Sick Building Syndrome and Its Related Factors in Nurses at Ali Ibn Abitaleb Hospital in Rafsanjan City 2018: A CrossSectional Study. J Rafsanjan Univ Med Sci 2020; 19 (6): 591602. [Farsi]