effects of aerobic training and combination of resveratrol and fisetin on brain neurogenesis signaling pathways in alzheimer’s mice

Background and aims: alzheimer’s disease (ad) is a brain disorder that slowly destroys memory through the destruction of neurons by activating bdnf/vegf/fgf7 signaling. the purpose of this study was to investigate the effects of aerobic training and combination of resveratrol and fisetin on brain neurogenesis signaling pathways in alzheimer’s mice. methods: in this experimental study, twenty-five c57bl/6j ad mice were randomized into 5 groups, including control, ad, ad+at, ad+rsv+fis, and ad+at+rsv+fis. the mice of the ad groups became ad by injecting amyloid-beta (aβ1)-42 into the hippocampus. the at protocol was five days per week for eight weeks before and after ad induction. rsv and fis with concentrations of 25 mg/kg and 20 mg/kg were used, respectively. one-way analysis of variance was utilized to compare different groups, and tukey’s post hoc test was employed at p≤0.05. results: ad induction caused a significant decrease in the expression of bdnf/vegf/fgf7 genes in hippocampal (p=0.001). at and consumption of rsv+fis significantly increased bdnf (p=0.001), vegf (p=0.001), and fgf (p=0.001) in hippocampal. conclusion: it seems that at and rsv+fis, both alone and simultaneously, can help increase brain neurogenesis in elderly people with ad by increasing the expression of bdnf, vegf, and fgf7 genes in the brain tissue.