the effect of 8 weeks of interval training combined with the consumption of cineole, linalool, and bourbonene on mapk/arc gene expression and learning in rats with alzheimer’s disease

Background and aims: this research aimed to investigate the effect of 8 weeks of interval training and the use of cineole, linalool, and bourbonene on mapk/arc gene expression and learning in alzheimer’s disease (ad) rats. methods: in this experimental study, 40 ad rats were randomized into eight groups, including (1) control, (2) ad, (3) ad + aerobic training (at), (4) ad + linalool, cineole, and bourbonene (lcb), (5) ad + at + lcb, (6) at + ad, (7) lcb + ad, and (8) at + lcb + ad. ad was induced by injecting amyloid-beta (aβ1)-42 into the hippocampus of rats. the interval training protocol was performed five days per week for eight weeks before and after ad induction. linalool at a concentration of 25 mg/kg, cineole at a concentration of 10 μm, and β-bourbonene at a concentration of 10 μg/ml were used for eight weeks. one-way analysis of variance was used for between-group comparisons, and tukey’s test was used for pairwise comparisons at p ≤ 0.05. results: ad induction caused a significant decrease in mapk/arc gene expression in hippocampal tissue (p = 0.001). interval exercise and consumption of three herbal drugs significantly increased gene expression of arc (p = 0.001) and mapk (p = 0.001). ad induction decreased learning (p = 0.001). interval exercise and consumption of three herbal medicines caused a significant increase in learning (p = 0.001). conclusion: interval exercise and using three herbal medicines have more favorable effects on improving mapk/arc gene expression and learning in ad than each alone.