the effect of eight weeks of high-intensity interval training with l-cysteine consumption on interleukin-13 and oxidative stress of heart tissue in young rats with type 2 diabetes

Background and aims: the purpose of this study was to investigate the effect of 8-weeks of high-intensity interval exercise with l-cysteine (lc) consumption on interleukin (il)-13 and hydrogen peroxide of the heart tissue in young rats with type 2 diabetes (t2d). methods: the statistical population of the present study consisted of young (4-month) rats with t2d. ten rats were selected as a healthy group. forty rats became diabetic. diabetic rats were randomly divided into diabetes control, diabetics with exercise, diabetics with supplements, and diabetics with exercise and supplements. high-intensity interval exercises were performed 3 days a week for 8 weeks, and 500 μmol of lc were injected daily. results: the healthy control group had lower il-13 than the control group (p=0.001). there was no significant difference in il-13 between other groups. based on the results, the diabetes control group had a higher h2 o2 value than the healthy control group (p=0.001). a significant difference was found between the exercise group+lc consumption compared to the diabetes control group, and the h2 o2 levels in this group were less than the diabetic control group (p=0.001). the exercise (p=0.015) and lc (p=0.001) groups had a lower h2 o2 value than the diabetes control group. eventually, the interval exercise group+lc was also lower than the periodic exercise group (p=0.02). conclusion: high-intensity interval training, along with the use of lc, reduced hydrogen peroxide in the heart tissue, while it had no significant impact on il-13.