the effect of eight weeks of moderate-intensity endurance training on serum levels of troponin i and b-type natriuretic peptide in radiotherapy rats

Background and aims: one of the most important potential problems of radiotherapy is the heart problem caused by this treatment. therefore, this research aimed to investigate the effect of 8 weeks of moderate-intensity endurance training on the serum levels of troponin i (tni) and brain (b-type) natriuretic peptide (bnp) in rats undergoing radiation therapy. ] methods: in this experimental study, 32 male rats (4-6 months) were randomly divided into four groups of eight, including healthy control (c), aerobic training (at), radiotherapy (rt), and at+rt groups. first, rats were anesthetized with ketamine-xylazine solution (k: 60-90 kg/mg, z: 6-10 kg/mg) and then located on a plexiglas plate with a thickness of 1 cm. photon beam rt was performed using x-rays with a dose of 11 gy from an elekta compact linear accelerator (elekta compact 6-mv china). at program was performed for eight weeks, five days a week, and one session a day for 60 minutes (70-75% of maximal oxygen consumption). finally, one-way anova was run to examine the research variables. results: the results showed that there was no significant difference between the groups in terms of the tni level (p=0.23). however, a significant difference was found in the amount of bnp between the rt and c groups (p=0.009). in addition, no significant difference was reported in terms of bnp between at+rt with at (p=0.99), rt (p=0.32), and c (p=0.69) groups, as well as between at with rt (p=0.1) and c (p=0.99) groups. conclusion: overall, radiation therapy caused a significant increase in bnp, but it had no significant effect on tni. aerobic training did not significantly affect tni and bnp in healthy rats and those undergoing radiation therapy.