the effect of resistance training on blood pressure, apelin, anp, pon1, adiponectin, h2o2, and et-1 in hypertensive men

Background and aims: primary hypertension, an unexplained increase in blood pressure (bp), accounts for 90% of the cases of hypertension and remains a critical public health challenge. this study aimed to investigate the effects of 12-week resistance training (rt) on some vasodilators and vasoconstrictors in hypertensive men. methods: this is a semi-experimental study. a total of 40 middle-aged men (45.3±3.2 years) with moderate hypertension (systolic bp [sbp] 140.5±0.3 and diastolic bp [dbp] 90.7±0.0 mm hg) were randomly divided into the rt (n=20) and non-exercise control (n=20) groups. the 12-week dynamic rt program was performed at an intensity of 80% of one repetition maximum for 3 days per week (3 sets of 8 repetitions/3 days a week). blood samples were taken from both groups at baseline and weeks 4, 8, and 12. results: sbp and dbp decreased by -8.19±2.46 mm hg (p=0.039) and -1.19±0.02 mm hg (p=0.033) from baseline at week 12 in the rt group, respectively, compared to the control group (sbp; 8.22±2.49, p=0.04; dbp; -1.19±0.03, p=0.032). adiponectin, apelin, atrial natriuretic peptide (anp), and paraoxonase-1 (pon-1) serum levels increased from baseline at weeks 8 (p=0.01) and 12 (p=0.01), while endothelin-1 (et-1) and h2 o2 decreased from baseline at weeks 8 (p=0.01) and 12 (p=0.01) in the rt in comparison to the control group. conclusion: overall, 12-week rt led to an increase in apelin, anp, pon-1, and adiponectin. increasing these markers reduces h2 o2 and et-1, thus decreasing sbp and dbp in hypertensive men.