the effect of eight-week resistance training and consumption of grape seed nanoparticles on mitochondrial biogenesis of heart tissue in the myocardial infarction model

Background and aims: the consumption of grape seed nanoparticles extract can control cardiovascular risk factors. exercise plays a protective role against cardiovascular disease. therefore, the aim of the present study was to investigate the effect of eight-week resistance training (rt) and the use of grape seed nanoparticles on mitochondrial biogenesis of heart tissue in myocardial infarction (mi) models. methods: in this experimental study, 25 rats were randomly divided into five groups including (1) control (c), (2) mi, (3) mi + rt, (4) mi + grape seed, and (5) mi + rt + grape seed. mi was induced by subcutaneous injection of isoprenaline (85 mg/kg). grape seed nanoparticles were daily administered at a dose of 150 mg/kg for 8 weeks, and rt was performed 5 days a week. finally, data were analyzed using the one-way analysis of variance (anova) and tukey’s post hoc tests (p ≤ 0.05). results: mi models showed decreased expression of pgc-1α, pparγ, and ucp-1 genes in cardiac tissue (p = 0.001). however, rt combined with the use of grape seed nanoparticles had a significant effect on increasing the expression of pgc-1α (p = 0.001), pparγ (p = 0.002), and ucp-1 (p = 0.003) genes in the heart tissue of mi model mice. conclusion: the consumption of grape seed nanoparticles along with rt has more effects on improving the expression of pgc-1α, pparγ, and ucp-1 genes in mi than either alone. therefore, the use of grape seed nanoparticles together with rt is recommended in case of mi.