modulatory effect of aerobic training on some inflammatory profile indicators in obese females

Introduction: it is widely accepted that low grade systemic inflammation plays a key role in obesity and related diseases and metabolic syndrome. the objective of this work was to evaluate the effect of aerobic training intervention on crp and il-10 in adult obese females. methods: thirty adult obese women (30≤bmi≤36) aged 30 to 40 years were randomly assigned to exercise (3 months aerobic training, 3 time per week at 60-75% of maximum heart rate, n=15) and control (no training, n=15). at baseline and after 3 months, anthropometrical indexes as well fasting serum il-10 and crp were assessed in 2 groups. inter and intra-group changes were analyzed by independent and paired sample t test. p<0.05 was considered statistically signigcant. results: after the 3 months of aerobic intervention, a significant decrease were observed in bmi, abdominal circumference, body weight, body fat (%) and visceral fat of exercise subjects (p<0.05). no significant difference was found in all variables between 2 groups at baseline (p>0.05). aerobic intervention resulted in significant increase in serum il-10 (from 14.79±3.04 to 17.79±3 pg/ml, p=0.001) and decrease in crp (from 5670±1971 to 3848±1092 ng/ml, p=0.002). all variables remained no change in control subjects (p>0.05). conclusion: with emphasis on il-10 and crp, long-term aerobic training can be considered as a anti-inflammatory treatment in sedentary obese females.