renoprotective effects of gaba on ischemia/reperfusion induced renal injury in hyperglycemic male and female rats

Introduction: acute kidney injury (aki) has been known as a complex clinical complication in diabetic patients. the main cause of aki is ischemia/reperfusion injury (iri). this study was designed to investigate the protective effects of gaba on renal iri in hyperglycemic female and male rats. methods: sixty stz induced diabetic male and female wistar rats were categorized in 10 groups (5 female &5 male groups). groups 1-3 in each gender received gaba (10, 50, 100μmol/kg/day) for 3 days, and then were subjected to renal iri .group 4 in each gender was subjected to renal iri alone, and group 5 was subjected to surgical operation without renal iri.24 hr after i/r injury, blood sample was obtained, and the animal were sacrificed for pathology investigation. results: renal iri alone increased the serum blood urea nitrogen levels (bun) and creatinine (cr), and kidney damage in both male and female rats significantly (p<0.05), however all doses of gaba decreased the serum bun and cr levels and tissue damage when compared with control group. conclusion: from the results of this study it seems that gaba administration in hyperglycemic rats could decrease renal injury after an ischemia/reperfusion.