Evaluation of frequency polymorphism Interleukin B1 gene in patients with peptic ulcer and chronic gastritis

Introduction: helicobacter pylori is the main cause of chronic inflammation and peptic ulcer. more than half of the world population is afflicted with helicobacter, while only 20% of people show the clinical symptoms of the disease. genes encoding the cytokines interleukin (il)-1b play a key role in the inflammatory responses of gastric mucus. this study aims to analyze polymorphism in the il-1b gene. methods: 107 individuals who showed the symptoms of chronic gastritis participated in the treatment group. individuals with no symptoms were considered as the control group. il-1b+3954c/t polymorphism was analyzed through pcr-rflp. results: there is no association between the presence of the t allele in an il-1b gene whit peptic ulcer and chronic gastritis as compared with control group (or=0.66, ci=0.34-1.27, or=0.75, ci=0.32-1.15) respectively.conclusion: our results suggest that there is no association between il-1b+3954 c/t polymorphism and peptic ulcer disease and chronic inflammation.