Effect of Citrullus Colocynthis pulp on renal function in streptozotocin-induced diabetic rats

Introduction: diabetic nephropathy is one of the most serious microvascular complications of diabetes and the main cause of end-stage renal disease. various herbs have been used to control diabetes complications. this study aimed at investigating the effect of citrullus colocynthis pulp on diabetes-induced renal damage in male rats.methods: a total of 36 rats were divided into 6 groups: 1- normal (n), 2- normal + 10 mg/kg colocynth (n+c10), 3- normal + 30 mg/kg colocynth (n+c30), 4- diabetic (d), 5- diabetic+10 mg/kg colocynth (d+c10), and 6- diabetic+30 mg/kg colocynth (d+c30). the rats received colocynth pulp through gavage for two weeks. the obtained data were analyzed through anova and tukey test using spss 16. results: the diabetic rats showed a sharp rise in the volume of urine, clearance of albumin, clearance of creatinine, and serum urea. administration of colocynth in diabetic rats improved the changes to normal.conclusion: the results of this study show that colocynth pulp has the potential to treat diabetes and to prevent the relevant kidney damages.