Comparison of the effect of Dexamethasone - Metoclopramide combination and ondansetron in the prevention of nausea and vomiting in cesarean section under spinal Anesthesia

Introduction: nausea and vomiting is one of the complications of spinal anesthesia in cesarean section. the aim of this study was to compare the effects of dexamethasone-metocloprmide with ondansetrone on preventing nausea and vomiting during spinal anesthesia for cesarean section. methods: in this study 212 pregnant women (17-45 years old) candidate for elective cesarean section with an asa i-ii were subjected to a randomized double blind clinical trial. before spinal anesthesia was applied the first group received 8 milligram dexamethasone and 10 milligram metoclopramide intravenously, the second group received 8 milligram ondansetrone intravenously. results: there were no significant differences between the two groups regarding the demographic variables, and also heart rate, systolic and diastolic blood pressures at before neuroaxial block and at 1, 3, 5 and 10 minutes after block. )p>0.05). the apgar score between the two groups was significantly different at the first (p=0.028), fifth (p=0.001) and twentieth minute (p=0.019). the overall incidence of nausea was 11.3% with no significant difference between the groups (p=0.665). no patient in the dexamethasone-metocloprimde group experienced any vomiting and in the ondansetrone group only 5 patients (4.7%) had vomiting (p>0.05). conclusion: the combination of dexamethasone and metocloprimde is effective in preventing nausea and vomiting during cesarean section in women who have no other pregnancy related complications.key