simultaneous effect of resistance training and folate nano-liposome on dopamine receptors in the brain hippocampus of alzheimer’s rats

Background: alzheimer’s is progressive dementia with loss of nerve cells. physical activity and the use of nano-pharmaceutical supplements may prevent the progression of alzheimer’s. the aim of this study was to investigate the effects of resistance training and folate nano-liposome on the expression of d1 and d2 receptors in the hippocampal tissue of alzheimer’s rats. methods: thirty-three male wistar rats at the age of eight weeks were prepared from pasteur institute and randomly divided into 5 groups (healthy control, alzheimer’s control, alzheimer+resistance training, alzheimer+folate nano-liposomes, and alzheimer+resistance training+folate nano-liposomes). alzheimer’s was induced, and folate nano-liposomes were injected as a supplement. the animals were anesthetized, and the hippocampus was analyzed after the last training session. eventually, a one-way anova test was used to estimate the differences between groups (p≤0.05). results: the results of one-way anova showed a significant difference between the groups in terms of d1 mrna and d2 mrna (p≤0.000). based on the results of the bonferroni post hoc test, there was a significant difference between the control group and the alzheimer’s, alzheimer’s+resistance training, and alzheimer’s+folate nano-liposomes. similarly, a significant difference was found between the alzheimer’s group and alzheimer’s+resistance training and alzheimer’s+resistance training+folate nano-liposomes (p≤0.05). conclusion: resistance training and folate nano-liposomes changed the content of d1 and d2 in the brain after alzheimer’s induction. these changes may be partly due to the synergistic effect of physical activity and nano-pharmaceuticals on preventing or reducing the detrimental effects of pathological conditions. inflammatory factors appear to be associated with neurotrophic factors during activity and exercise in neurodegenerative diseases.