Effect of High-Intensity Interval Training with Eryngium Campestre on Lipid Profile and Glycemic Indices in High-Fat Diet-Induced Obese Rats

Background: obesity is a multi-factorial physical disorder that results in high serum lipid levels and glycemic disorders. on the other hand, regular exercise and administration of eryngium campestre (ec) have glucose and lipid-lowering effects. objectives: the present study aimed to review the effect of high-intensity interval training (hiit) with ec on lipid profile and glycemic indices in high-fat diet (hfd)-induced obese rats. methods: twenty-four obese rats were divided into four groups, including: (1) control, (2) hiit, (3) ec, and (4) hiit+ec. to investigate the effect of obesity on research variables, six rats were assigned to a healthy control group. during six weeks, groups 2 and 4 received hiit three days per week, and groups 3 and 4 received 30 mg/kg ec by gavage. data were analyzed using the shapiro-wilk test and one-way anova with tukey’s post hoc test (p≤0.05). results: obesity significantly increased cholesterol (cho), triglyceride (tg), insulin, and glucose levels (p ≤ 0.05). however, hiit significantly decreased cho, tg, insulin, and glucose levels (p≤0.05), and ec significantly decreased cho, tg, low-density lipoprotein (ldl), insulin, and glucose levels (p≤0.05). besides, hiit+ec significantly decreased ldl and insulin (p≤0.05). hiit+ec could decrease ldl more than did hiit (p≤0.05). conclusions: although hiit and ec alone improved the lipid profile and glycemic indices in obese rats, hiit combined with ec had greater effects on the decrease of ldl compared to hiit.