sensitivity and specificity of measuring anti-müllerian hormone and follicle stimulating hormone levels in predicting response to ovarian stimulation in infertile women

Background and objective: assisted reproductive technologies (art), including in vitro fertilization (ivf) and embryo transfer, have achieved considerable success, largely due to controlled ovarian hyperstimulation (coh). however, there remains a shortage of studies on the estimation of various ovarian response markers linked to the gnrh agonist-controlled ovarian stimulation (cos) regimen. the objective of the current study is to assess the productiveness of follicle stimulating hormone (fsh) and anti-mullerian hormone (amh) in determining ovarian responses in infertile patients undergoing controlled ovarian stimulation.methods: this cohort study involved 90 females, aged 20 to 43 years, with primary and secondary infertility lasting between 3 and 13 years, attending the al-najef fertility center for icsi cycles between june 2020 and january 2021. patients with a history of ovarian surgery, polycystic ovary syndrome (pcos), and premature ovarian failure (pof) were excluded. fsh and amh levels were calculated on second 2 of the menstrual cycle, and the association between these indicators and outcome factors was evaluated.findings: amh demonstrated a negative link with age and a positive link with the antral follicle count, total number of follicles after induction, and retrieved oocyte count (p<0.05). fsh exhibited a significant negative link by the total number of follicles after induction (p<0.05). amh demonstrated the best sensitivity and specificity, positive predictive value (ppv) and negative predictive value (npv) for predicting ovarian response. specificity, sensitivity, ppv and npv for amh with cut-off values >2 ng/ml test providing 84%, 80%, 86%, 57% in comparison to fsh with cut-off values >4 iu/ml yielded 67%, 68%, 50% and 54%, respectively.conclusion: in conclusion, our findings suggest that amh is a superior predictor of ovarian response compared to fsh.

sensitivity and specificity of measuring anti-müllerian hormone and follicle stimulating hormone levels in predicting response to ovarian stimulation in infertile women

background and objective: assisted reproductive technologies (art), including in vitro fertilization (ivf) and embryo transfer, have achieved considerable success, largely due to controlled ovarian hyperstimulation (coh). however, there remains a shortage of studies on the estimation of various ovarian response markers linked to the gnrh agonist-controlled ovarian stimulation (cos) regimen. the objective of the current study is to assess the productiveness of follicle stimulating hormone (fsh) and anti-mullerian hormone (amh) in determining ovarian responses in infertile patients undergoing controlled ovarian stimulation.methods: this cohort study involved 90 females, aged 20 to 43 years, with primary and secondary infertility lasting between 3 and 13 years, attending the al-najef fertility center for icsi cycles between june 2020 and january 2021. patients with a history of ovarian surgery, polycystic ovary syndrome (pcos), and premature ovarian failure (pof) were excluded. fsh and amh levels were calculated on second 2 of the menstrual cycle, and the association between these indicators and outcome factors was evaluated.findings: amh demonstrated a negative link with age and a positive link with the antral follicle count, total number of follicles after induction, and retrieved oocyte count (p<0.05). fsh exhibited a significant negative link by the total number of follicles after induction (p<0.05). amh demonstrated the best sensitivity and specificity, positive predictive value (ppv) and negative predictive value (npv) for predicting ovarian response. specificity, sensitivity, ppv and npv for amh with cut-off values >2 ng/ml test providing 84%, 80%, 86%, 57% in comparison to fsh with cut-off values >4 iu/ml yielded 67%, 68%, 50% and 54%, respectively.conclusion: in conclusion, our findings suggest that amh is a superior predictor of ovarian response compared to fsh.