the relationship between reproductive hormones, mfg-e8, and chlamydial infection in infertile women

Background and objective: chlamydia trachomatis (ct) is a common sexually transmitted infection that is often symptomless and can cause long-term complications, including infertility. the objective of this study is to evaluate the relationship between reproductive hormones, mfg-e8 (milk fat globule-epidermal growth factor 8), and chlamydial infection in infertile women.methods: this cross-sectional study was conducted in al-salama hospital between november 2021 and february 2023 on 90 participants, 60 infertile patients and 30 fertile individuals as a control group. the participants were divided into four groups based on their chlamydial infection status and serum levels of ct ig-g, mfg-e8, amh (anti-müllerian hormone), lh (luteinizing hormone), and fsh (follicle-stimulating hormone), prolactin, and testosterone were measured and compared using the elisa technique.findings: a notable difference in ig-g levels was observed based on chlamydia trachomatis infection status of female participants. the infertile group demonstrated significantly higher ig-g levels, with a mean of 17.22±6.43 in the presence of positive chlamydial infection, compared to the other groups (p<0.0001). in addition, the mean level of mfg-8 in the fertile group with chlamydia positive, at 215.65±26.07 ng/ml, was significantly higher compared to other groups (p<0.0001). no statistically significant difference was observed in mfg-e8 level between fertile and infertile patients.conclusion: the results of the study revealed a significant link between chlamydia trachomatis infection and infertility. the fertile women with chlamydia-positive cases exhibited elevated levels of mfg-8, suggesting its potential involvement in reproductive health. these findings contribute to our understanding of the complex relationship between chlamydia trachomatis infection, reproductive hormones, and infertility.

the relationship between reproductive hormones, mfg-e8, and chlamydial infection in infertile women

background and objective: chlamydia trachomatis (ct) is a common sexually transmitted infection that is often symptomless and can cause long-term complications, including infertility. the objective of this study is to evaluate the relationship between reproductive hormones, mfg-e8 (milk fat globule-epidermal growth factor 8), and chlamydial infection in infertile women.methods: this cross-sectional study was conducted in al-salama hospital between november 2021 and february 2023 on 90 participants, 60 infertile patients and 30 fertile individuals as a control group. the participants were divided into four groups based on their chlamydial infection status and serum levels of ct ig-g, mfg-e8, amh (anti-müllerian hormone), lh (luteinizing hormone), and fsh (follicle-stimulating hormone), prolactin, and testosterone were measured and compared using the elisa technique.findings: a notable difference in ig-g levels was observed based on chlamydia trachomatis infection status of female participants. the infertile group demonstrated significantly higher ig-g levels, with a mean of 17.22±6.43 in the presence of positive chlamydial infection, compared to the other groups (p<0.0001). in addition, the mean level of mfg-8 in the fertile group with chlamydia positive, at 215.65±26.07 ng/ml, was significantly higher compared to other groups (p<0.0001). no statistically significant difference was observed in mfg-e8 level between fertile and infertile patients.conclusion: the results of the study revealed a significant link between chlamydia trachomatis infection and infertility. the fertile women with chlamydia-positive cases exhibited elevated levels of mfg-8, suggesting its potential involvement in reproductive health. these findings contribute to our understanding of the complex relationship between chlamydia trachomatis infection, reproductive hormones, and infertility.