شیوع هپاتیتb مخفی در بیماران دیالیزی مراجعه کننده به مرکز دیالیز شهرستان ساری

سابقه و هدف: یکی از عوامل احتمالی ادامه عفونت هپاتیت b در بالغین همودیالیزی وجود هپاتیت b مخفی است. با توجه به این که احتمال وجود عفونت مخفی هپاتیت b در بین بیماران نقص ایمنی به ویژه همودیالیزی وجود دارد، هدف از این مطالعه بررسی میزان فراوانی هپاتیتb مخفی در بیماران دیالیزی شهرستان ساری بوده است.مواد و روش‌ها: در این مطالعه توصیفی- مقطعی که در سال 1398 در شهر ساری انجام شد. خون‌گیری در بیماران دیالیزی، قبل از دیالیز انجام شد و سپس تست‌های سرولوژی با استفاده از کیت‌های مخصوص با روش الایزا از نظر hbs-ab,hbs-ag و hbv pcr,hbc-ab انجام شد. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری spss انجام شد. برای ارتباط بین متغیرهای کیفی از آزمون chi-square استفاده شد. هم‌چنین برای مقایسه بین دو گروه از آزمون تی‌مستقل استفاده شد و مقدار p>0/05 به‌عنوان سطح معنی‌داری در نظر گرفته شد.یافته‌ها: تعداد افراد مورد بررسی در این مطالعه 279 نفر بودند. آزمون مجذور کای نشان داد که تفاوت معنی‌داری بین دو گروه از لحاظ جنس وجود نداشت (0/05p). هم‌چنین نشان داده شد که رابطه معنی‌داری بین هپاتیت b مخفی و اطلاعات دموگرافیک مورد بررسی وجود ندارد (0/05

prevalence of occult hbv infection in dialysis patients referred to sari dialysis center

background and purpose: one of the possible factors for the continuation of hepatitis b infection in hemodialysis adults is the presence of hidden hepatitis b. considering the risk of occult hepatitis b infection in people with immunodeficiency disorders, especially hemodialysis patients, the aim of this study was to investigate the frequency of occult hepatitis b among dialysis patients in sari.materials and methods: this cross-sectional descriptive research was conducted in sari, 2018. blood samples were taken from dialysis patients before dialysis. then, hbv serology tests (hbs-ab, hbs-ag, hbv pcr, and hbc-ab) were performed using elisa method. data analysis was done using spss v20. chi-square test was used to find correlation between qualitative variables. also, the differences were compared using independent t-test, and p<0.05 was considered significant.results: a total of 279 dialysis patients were investigated in this study. the chi-square test showed that there was no significant difference between the two groups in terms of gender (p>0.05), but significantly, the majority of the studied patients had a previous history of diabetes and high blood pressure (p<0.05). the findings revealed that there was no significant relationship between latent hepatitis b and demographic information (p>0.05). independent t-test showed that the average age of people with latent hepatitis b was significantly higher than the rest of dialysis patients. (p=0.030). of the patients, nine (3.23%) had positive hbs-ag, of whom seven were under treatment and two did not need any treatment. despite two complete series of vaccination against hepatitis b, six patients (2%) with negative hbs-ag and hbs-ab were reported to have positive hbc-ab. two cases of them (0.71%) were pcr positive, which were real latent hepatitis, and four others were recorded as old recovered hepatitis.conclusion: the findings suggested that hbs-ag was a necessary but not sufficient factor in patients with end-stage renal disease (esrd); therefore, it was recommended to evaluate hbc-ab and to test pcr for positive cases.