اثر گز سین‌بیوتیک بر عملکرد انسولین و پروتیین واکنش‌گر C با حساسیت بالا در زنان باردار

Background: although much effort has gone into decreasing insulin resistance and inflammatory factors by consumption of probiotic-containing products in pregnant women, limited data are available assessing the effects of synbiotic foods.objective: the aim of this study was to determine the effects of synbiotic gaz consumption on insulin function and serum high sensitivity c-reactive protein (hs-crp) levels in iranian pregnant women. methods: this randomized placebo-controlled clinical trial was conducted in 52 primigravida pregnant women aged 18-35 years old in the third trimester during 2012. after a 2-week run-in period, subjects were randomly allocated to consume either synbiotic (n=26) or control gaz (n=26) for 9 weeks. each gram synbiotic gaz consisted of a probiotic lactobacillus sporogenes (1×107 cfu), 0.04 g inulin as prebiotic with 0.38 g isomalt, 0.36 g sorbitol and 0.05 g stevia as sweetener. control gaz (the same substance without probiotic bacteria and inulin) was packed in identical 9-gram packages. fasting plasma glucose (fpg), insulin function and serum hs-crp levels were measured at baseline and after a 9-week intervention. data were analyzed using independent sample t-test, paired t-test, anova, ancova, mann whitney u test and wilcoxon signed rank test.findings: the following changes were statistically significant compared with the control group: decrease in insulin levels (-0.26 vs. 6.34 µiu/ml, p=0.014) and homa-ir (-0.13 vs. 1.13, p=0.033), difference in homa-b (5.30 vs. 34.22, p=0.040) and increase in quicki (0.002 vs. -0.02, p=0.022). the differences for fpg and hs-crp levels were not statistically significant. conclusion: with regards to the results, consumption of synbiotic gaz for 9 weeks had beneficial effects on insulin function among pregnant women, but did not affect fpg and serum hs-crp levels.