مقایسه تاثیر درمان با انسولین تنها و انسولین به علاوه سولفونیل اوره در بیماران دیابتی نوع دو

Background: insulin is administered for glycemic control in type 2 diabetic patients with secondary failure to oral antidiabetic drugs. achieving good glycemic control requires a long time with relatively high insulin dose.objective: the aim of this study was to compare the effect of treatment with insulin alone versus insulin plus sulfonylurea in type 2 diabetic patients.methods: in this randomized clinical trial, 45 patients with secondary failure to oral antidiabetic drugs who referred to bou-ali hospital during 2009-2010, were randomly allocated into two groups of insulin alone and insulin plus sulfonylurea. fasting and postprandial blood sugar, insulin dose, and weight gain were measured monthly up to 3 months. data were analyzed by t-test and chi-square test.findings: at the end of the first and the third month of the treatment, mean fasting blood sugar was 146.3±21.1 mg/dl and 126.9±10.2 mg/dl in combination therapy group and was 166.1±28.7 mg/dl and 144.5±20.9 mg/dl in insulin alone group, respectively (p=0.01 and p=0.001, respectively). mean postprandial blood sugar in combination group was lower than insulin alone group at the end of the third month (p=0.009). the difference in mean insulin dose between 2 groups was statistically significant at the end of the third month (p < 0.001). conclusion: with regard to the results, combination therapy with insulin plus sulfonylurea versus insulin alone would result in faster improvement of glycemic control and lower daily insulin dose.