شیوع متالوبتالاکتاماز در بین گونه های آسینتوباکتر جدا شده از نمونه های بالینی

Background: imipenem-resistant acinetobacter spp. resulting from metallo-b-lactamase (mbls)-producing strains have been reported to be among important causes of nosocomial infections and of serious therapeutic problem worldwide.objective: to determine the prevalence of metallo-b-lactamase among imipenem-resistant acinetobacter isolates based on phenotypic methods.methods: this was an descriptive study in which 140 clinical isolates of acinetobacter spp. were initially tested for imipenem susceptibility and later for metallo-b-lactamase production using combined disk diffusion, double disk synergy test, and hodge test during 2010. antibiotic susceptibility of positive metallo-b-lactamase isolates were further evaluated by disk diffusion technique using clsi methodology.findings: of 140 isolates, 29 (20.7%) were imipenem-resistant acinetobacter. positive phonetypic test for metallo-b-lactamase was 24 (17.1%).conclusion: the result of this study is indicative of growing number of nosocomial infections associated with multidrug-resistant acinetobacter spp. in this region leading to difficulties in antibiotic therapy.