programmed cell death 1 gene polymorphism as a risk factor for systemic lupus erythematosus in northwest iran

Background: systemic lupus erythematosus (sle) is a chronic autoimmune disease. the programmed cell death 1 (pdcd1) gene, which encodes the pd1 protein, is one of the many genes involved in susceptibility to sle. the pd1 protein is an inhibitory immunoreceptor that plays a key role in maintaining immunological tolerance to self-antigens. the pd1.5 c/t polymorphism (rs2227981, c.804 t > c) alters the expression and function of the pd‐1 receptor.objectives: this case-control study aimed to determine the association between the rs2227981 polymorphism of the pdcd1 gene and susceptibility to sle in the northwestern population of iran.methods: the rs2227981 genotype was determined in 52 sle patients and 53 controls using the pcr-rflp method with the pvu ii restriction enzyme.results: the study found a significant association between the rs2227981 polymorphism and susceptibility to sle in the study population.conclusions: the rs2227981 polymorphism appears to be a risk factor for sle in northwestern iran.