the inflammatory markers c-reactive protein and mean platelet volume in chronic kidney disease

Background: people with chronic kidney disease (ckd) experience chronic systemic inflammation. although a relationship exists between inflammation and renal injury, the association between inflammatory markers and renal disease has not been well-studied. as inflammation may be a trigger or a result of chronic disease, the kidney needs to be investigated to determine whether it is a clearer target for the devastating effects of persistent inflammation. here, we report the relation of c-reactive protein and mean platelet volume levels with renal functions in chronic kidney disease patients. methods: this study was an observational retrospective single-center study conducted on the record of ckd patients to detect the outcomes over a median follow-up time of three years. demographic, clinical, laboratory, medication, and outcome data were obtained from the electronic data records of the hospital. we investigated the multivariable association of plasma levels of c-reactive protein and mean platelet volume with the progression of ckd in the study participants. findings: elevated plasma levels of c-reactive protein (r=0.13, p<0.001) and mean platelet volume (r=0.23, p<0.001) were associated with a greater loss of kidney function over time. the presence of diabetes mellitus was detected to be a risk factor for ckd progression (p=0.04). an inverse relationship was detected between sodium and creatinine (p<0.001). in addition, a weak association was detected between uric acid and creatinine (p<0.001). conclusion: elevated plasma levels of c-reactive protein and mean platelet volume were associated with a decline in the estimated glomerular filtration rate in patients with ckd.