association of two mmp-8 gene polymorphisms with recurrent pregnancy loss in iranian women

Background: it has been reported that less than 5% of women experience recurrentpregnancy loss (rpl). different matrix metalloproteinases (mmps) have proteolysisfunction with a main role in the stable development of the fetus.objective: this study aims to assess the associations between two single nucleotidepolymorphisms (rs2509013 c>t and rs11225395 g>a) of mmp-8 gene and rpl among130 iranian women with a history of rpl and 130 controls.methods: genotyping of the mmp-8 gene was done for the two polymorphisms by usingsanger sequencing method.results: high frequency of aa genotype (or: 2.5, 95%ci:1.02-4.1, p<0.01) and a allele(or:1.95, 95% ci:0.95-3.1, p<0.001) of rs11225395 g>a polymorphism in patientscompared to controls. this high frequency was also reported in the haplotypes andcombined genotypes of polymorphism.conclusion: the mmp-8 gene may be involved in rpl risk and is a potential biomarkerfor rpl susceptibility.