The Effects of Prenatal Norharman Exposure on Seizure Severity in Rats

Background: norhraman is an alkaloid that can damage the nervous system. objective: this experimental study aimed to investigate the effects of prenatal norharman exposure on seizure severity in adult rats. methods: a total of 36 wistar rats were randomly divided into 3 groups as follows: control, sham (solvent), and norharman (1000 ug/kg). the sham and norharman groups were treated once daily for 8-18 of the fetal period. 2 months after birth, kindling was performed by the daily injection of pentylenetetrazol (ptz) (30 mg/kg); then, the seizure behavior was recorded for approximately 30 minutes. the obtained data were analyzed using analysis of variance (anova) and tukey’s posthoc test. results: the present study data indicated that administrating norharman in the fetal period increased seizure responses to ptz, i.e., significant in the examined female rats (p<0.05). conclusion: according to the current research findings, the severity of seizures increases in subjects who have been exposed to norharman during the prenatal period.